Most Replayed Moment: Alzheimer's Starts 20 Years Before Symptoms! How To Protect Your Brain Now
How do I best protect my brain from cognitive decline?
Louisa Nicola is a neurophysiologist and the founder of Neuro Athletics, specialising in brain health, human performance, and longevity.
In this Moment, Louisa Nicola reveals how the right kind of exercise can help protect the ageing brain, why one often-overlooked measure of physical strength may be a powerful marker of cognitive health, and the training approach linked to remarkable changes in the middle-aged heart.
Listen to the full episode here!
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How to be fearlessly AI native
Ryan welcomes McLaren Stanley, Senior Principal Engineer for Amazon Stores, to discuss what it actually takes to make teams AI native, why agentic engineering is shifting code bottlenecks downstream to testing and deployment, and why robust validation is essential to build trust and enable “fearless commits.”
Episode notes:
You can learn more about how Amazon’s frontier teams became AI native on the AWS blog.
Connect with McLaren on LinkedIn.
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Suno adds watermarks for AI music spam | Google Maps books hotels
In this episode, we discuss the implications of Suno's new restrictions on AI music downloads amidst ongoing legal challenges and the rise of AI music spam. We also explore significant developments from companies like Mirindle, Google Maps, and Naive, revolutionizing AI capabilities across various industries.
Chapters
00:00 Suno Introduces Download Limits
00:31 Google Cloud's Major AI Partnership
00:50 The Future of Google Maps
01:59 AI Social Media Moderation Issues
07:29 Startup Spotlight: Naive's Funding
16:00 Conclusion and AI Box Overview
Show Links
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703: Part of a Healthy Breakfast
Pre-show: The Overcast “kicking machine”
Adam Wunn’s blog post
Previously in ATP #324: Automatic Kicking Machine
Follow-up:
Marco gives John the gift of transcript search in build #1169 [The system works! — Ed.]
Build #1172 includes Siracusa Replay Mode
Be wary of Sonos + Pi-hole or other ad blockers (via Will Smidlein)
Ubiquiti High Availability
Redundant Power Supply USP-RPS
SmartPower Cable USP-Cable
“Odd” RAM amounts (via Joe Lion)
Multiple Apple accounts (via TJ Usiyan)
Some science about Sony’s axe of PlayStation discs
SuperDuper 4
Previously in the SuperDuper blog…
Apple Upgrade Program
John Voorhees at MacStories
The Verge with example numbers
Apple Upgrade vs. iPhone Upgrade
“Restricted Mode” isn’t about this
Is it worth it? Joe Rossignol answers
macOS 26.4 adds Battery Charge Limit
Ask ATP:
What are good backup strategies? (via Todd Vaziri)
Backblaze (former sponsor)
Tailscale (former & future sponsor)
What the heck is a Docker container? (also via Todd Vaziri)
Wizard zine
Post-show: Casey is car shopping again
Visor
AutoTempest
Bimmer.work
Driveway
Safari extension screenshot
Members-only ATP Overtime: OpenAI hardware progress
Codex Micro
Gruber
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Google’s AI Leadership Shakeup: Disaster or Exactly What It Needs?
Demis Hassabis is relinquishing day-to-day control of DeepMind, Jeff Dean is leaving Google after 27 years, and both moves follow a string of other marquee departures. Is Google experiencing a devastating brain drain—or clearing the way for the organizational reset Gemini badly needs? In the headlines: Meta releases two new models and its first coding harness, Anthropic starts building a chip team, and AI-driven shopping sends Shopify soaring.
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615: Upgrade*
Stephen and Myke are joined by Jason Snell to talk about CarPlay on boats and the new version of Pastebot, before useful consumer advice is given about weather stations and network-attached storage.
This episode of Connected is sponsored by:
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Upgrade #631: Nessie Beneath the Waves - Relay
Google Health Now Syncs With Apple Health - 512 Pixels
Garmin’s new screen-free fitness tracker doesn’t require a subscription | The Verge
CarPlay is Coming to Pontoon Boats - MacRumors
CarPlay is Coming to… Pontoon Boats — Liss is More
More Boats - Robot or Not? #357 - The Incomparable
Savvy Navvy
Pastebot 3 for Mac
Pastebot 3 Doubles Down on Mac Clipboard Automation and Introduces Two New Business Models - MacStories
Ambient WS-2000
The 3 Best Home Weather Stations of 2026 | Reviews by Wirecutter
DiskStation® DS925+ | Synology Inc.
Synology DS925+ 4-Bay 16TB NAS w/ 4x4TB HAT3300 Hard Drive Bundle
OWC ThunderBay 4: Thunderbolt 4-Bay RAID Storage
A new Mac mini: I want to believe – Six Colors
The next big thing in movies is 60-year-old IMAX tech
Christopher Nolan's The Odyssey is the first feature film ever shot entirely with IMAX 70mm film cameras, which is apparently a very big deal, and why it's been harder than usual to get a ticket to see Matt Damon. And now that Spider-Man is moving onto IMAX screens, it may be even harder to get a ticket. Why is this 60-year-old technology suddenly the hottest thing in movies? The Verge's film and TV reporter Charles Pulliam-Moore joins senior reviewer Jennifer Pattison Tuohy to compare the standard and IMAX versions of The Odyssey and talk us through the difference between IMAX, LieMAX, and Infinity Vision.
Further reading:
Christopher Nolan’s Odyssey will be the first movie shot entirely on IMAX film
Don’t screw this up, Marvel
The Odyssey turned me into an IMAX believer
Google just announced a major shakeup of its top AI leadership
Nintendo beats earnings thanks to US tariff refunds it won’t share with gamers
Bose’s upgraded QuietComfort headphones add head-tracking immersive audio
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Bose Releases Lighter QuietComfort Headphones That Bring Features from Ultra - DTNS 5326
It’s the first new Bose QuietComfort headphones in three years. Plus, Dolby Vision 2 comes to HiSense, a Samsung soundbar that doesn’t need a subwoofer, and smart glasses displays that don’t need prescription inserts.
Starring Tom Merritt and Huyen Tue Dao
Show notes can be found here.
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Meta Can Code Too!
Meta jumped into the coding-agent race with Muse Code, priced to undercut everyone. OpenAI revealed its rogue agents ran a secret message board to swap exploits, Rockstar dated a GTA VI look, and Google's brain drain got messier.
Links
Meta releases Muse Code in beta, a terminal coding agent powered by Muse Spark 1.2, a coding-focused model priced at $1.25/1M input and $4.25/1M output tokens (CNBC)
Meta says its Muse Spark 1.1 model exploited a vulnerability in another third-party service during cybersecurity testing, after evaluations firm Irregular caused the misconfiguration (The Information)
OpenAI says the Hugging Face breach involved AI agents creating an internal message board, unnoticed by humans, where they shared exploits and planned the hacks (Wired)
Rockstar says it will show an "extended look" at Grand Theft Auto VI on August 27, premiering on Netflix at 3pm ET before streaming on YouTube at 9pm ET (The Verge)
Sources: Demis Hassabis had been drifting away from Google DeepMind CEO day-to-day duties for at least a year and struggled to get satisfaction out of the role (Semafor)
Sources: Google researchers are frustrated over compute access as Cloud sells TPUs to rivals like Anthropic, amid an exodus that now includes all eight "Attention Is All You Need" authors (CNBC)
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Why People Are Paying 10x More for AI | Sid Sheth, d-Matrix
The AI chip market looks monolithic from the outside - NVIDIA dominates, and everyone else is fighting for scraps. But d-Matrix's CEO Sid Sheth argues that the market is quietly splitting into two distinct tiers, and the one that's exploding right now is the one NVIDIA's architecture isn't built for. In this episode, Sid joins Craig Smith to explain the "premium token economy": a new class of AI inference where interactivity is the product, users pay ten times more per million tokens for instant responses, and the memory bandwidth limits of GPU-based systems create a structural ceiling that purpose-built architectures don't have.
The conversation is unusually candid about what AI actually looks like at the executive level: Sid describes using Claude as a sounding board for M&A strategy, producing full integration plans in 15 minutes that used to require entire banking advisory teams, and watching AI shift from a tool that echoed his ideas back at him to one that genuinely disagrees, flags what he missed, and pushes back with enough confidence to be useful. He also makes the case that we're at the beginning of a shift from individual agents to what he calls "organizational AI" - teams of agents running entire company functions at a high level of abstraction - and that the infrastructure bet d-Matrix is making positions them directly in the path of that wave.
Subscribe to Eye on A.I. for weekly conversations with the people building and deploying the future of AI.
The Chopping Block: ColdCard's $100M RNG Hack, AI-Powered Security & Ethereum's Staking Yield Taper
This week we dissect ColdCard's ~$100M RNG exploit that Claude Code cracked in 8 minutes, debate whether AI just killed open-source security and Bitcoin maximalism, tear apart Ethereum's EIP-8361 staking-yield taper, and unpack Leopold Aschenbrenner's 67% Situational Awareness blowup and CLARITY Act's ethics fight.
Welcome to The Chopping Block – where crypto insiders Haseeb Qureshi, Tom Schmidt, Tarun Chitra, and Robert Leshner chop it up about the latest in crypto. No guest this week, just the four of them working through a week where AI quietly rewrote the economics of both security and human psychology, and crypto happened to be standing in the blast radius.
This episode: ColdCard, NVK's Bitcoin-only hardware wallet, got drained of nearly $100M thanks to a random-number-generation bug that a one-word commit buried five years ago, and Claude Code sniffed it out in 8 minutes (an open model with no internet found it in 20, for about two bucks). The crew debates whether AI just killed open-source security, whether Nic Carter is right that this is 'the death of Bitcoin maximalism,' and why Tarun thinks maxi devs are 'the RFK of security practices.' Then they take a blowtorch to Ethereum's EIP-8361 staking-yield taper (Tarun: 'the proposal reads like shit'), unpack Leopold Aschenbrenner's 67% Situational Awareness blowup while 4x levered, and wade into the CLARITY Act's ethics fight where a single amendment is the whole ballgame.
Listen to the episode on Apple Podcasts, Spotify, Pods, Fountain, Podcast Addict, Pocket Casts, Amazon Music, or on your favorite podcast platform.
Show highlights
🔹 ColdCard's Bitcoin-only hardware wallet drained of nearly $100M after a five-year-old random-number-generation bug silently fell back to weak software RNG.
🔹 A single dev swapped C++ macros with a one-word commit message, seemingly just to get NVK's code to compile, and doomed years of keys.
🔹 Claude Code found the ColdCard bug in 8 minutes; open model GLM 5.2, no internet, found it in ~20 for about $2.
🔹 Tarun calls Bitcoin maxi devs 'the RFK of security practices' who 'don't do audits,' branding ColdCard's lack of hardening 'incredibly delinquent.'
🔹 Haseeb warns AIs 'are much less diverse than humans,' so security now scales with AUM while North Korea spends thousands in compute.
🔹 Nic Carter calls it 'the death of Bitcoin maximalism' as Haseeb reads posts from holders who scrimped for three Bitcoin and woke up wiped.
🔹 EIP-8361 from Pintail and Justin Drake tapers ETH staking yield toward zero above 50% staked; the community is 'vomiting all over' it.
🔹 Tarun torches EIP-8361 as 'a truly horrendous post,' arguing constantly changing policy means Ethereum is never credible hard money.
🔹 Leopold Aschenbrenner's Situational Awareness AI hedge fund blew up ~67% while 4x levered, with Robert drawing Archegos comparisons.
Hosts
⭐️Haseeb Qureshi, Managing Partner at Dragonfly
⭐️Tom Schmidt, General Partner at Dragonfly
⭐️Tarun Chitra, Managing Partner at Robot Ventures
⭐️Robert Leshner, Founder & CEO of Superstate
Disclosures
Timestamps
00:00 Intro
01:03 ColdCard's $100M Exploit
05:46 AI, Audits & Bitcoin Maxi Security Failures
12:07 Open Source vs Closed Source in the AI Era
23:21 EIP-8361: Ethereum's Staking Yield Taper
30:34 Hard Money, Post-Quantum & Central Bank Chaos
35:54 Aschenbrenner's Situational Awareness Blowup
44:41 Robinhood Prediction Markets Boom as Hyperliquid RWAs Flip Crypto
51:54 Korea's Bloodbath & the Death of Retail Volatility
55:17 CLARITY Act: Ethics Provisions Are the Linchpin
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Chasing Trillion-Dollar Companies, Founder Ambition, Token Budgets, and Regulatory Capture with Sarah & Elad
Is the tech industry moving too quickly, or are founders letting fear of AI labs stunt their ambitions? Sarah and Elad explore the current landscape of artificial intelligence, venture capital, and startup dynamics. They discuss the realities of building multi-trillion-dollar companies, shifting market sizes and outcome-based pricing models, and how founders are reacting to the rise of major AI labs. They also talk about what the framework for startup exits should look like, the potential for researcher burnouts in the next eighteen months as ASI looms on the horizon, bottlenecks for compute, and the impact of regulatory capture and shifting ecosystems from California to Texas.
Apply for Embed - Conviction’s Catalyst for AI-Native Startups
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Follow us on Twitter: @NoPriorsPod | @Saranormous | @EladGil
Chapters:
00:00 – Cold Open Trailer
00:31 – Episode Introduction
01:44 – The Next Trillion-Dollar Company
03:12 – Tech Waves as Punctuated Equilibria
04:42 – TAM vs. Revenue Reality
07:14 – Market Size vs. Speed
10:32 – When Founders Should Sell
14:04 – Financing and Time Cost
17:57 – RSI and the Looming Promise of ASI
21:49 – Compute Power Laws
28:12 – Regulations and Disruption
33:06 – Beyond Transformers
34:26 – Tradeoffs - Safety vs. Progress
39:11 – Conclusion
9 drunk ideas that sound stupid (but are secretly genius)
Business Ideas Database: https://clickhubspot.com/erhy
Episode 849: Sam Parr ( https://x.com/theSamParr ), Shaan Puri ( https://x.com/ShaanVP ) and their producer Arie brainstorm 9 business ideas that are genius.
—
Show Notes:
(0:00) Intro
(2:07) IDEA 1: Reverse vacations
(6:03) IDEA 2: Rap battle + UFC fight
(13:18) IDEA 3: Giant claw machine
(20:39) IDEA 4: Butter dispenser
(27:32) IDEA 5: beepers for kids
(35:35) IDEA 6: Mexican Benihana
(40:01) IDEA 7: bulk custom gifts
(44:10) IDEA 8: Slop Stop
(49:06) IDEA 9: Take your roommate to work day
—
Check Out Sam's Stuff:
• Hampton (joinhampton.com): My community for founders. Average member does $25m/year. Many of the guests are members. Get after it...apply: http://joinhampton.com/mfm
—
Check Out Shaan's Stuff:
• Shaan's weekly email - https://www.shaanpuri.com
• Visit https://www.somewhere.com/mfm to hire worldwide talent like Shaan and get $500 off for being an MFM listener. Hire developers, assistants, marketing pros, sales teams and more for 80% less than US equivalents.
• Mercury - Shaan uses Mercury across all of his companies. you can too: http://mercury.com/
Mercury is a fintech company, not an FDIC-insured bank. Banking services provided by Choice Financial Group, Column, N.A., Members FDIC
• I run all my newsletters on Beehiiv and you should too + we're giving away $10k to our favorite newsletter, check it out:
beehiiv.com/mfm-challenge
My First Million is a HubSpot Original Podcast // Brought to you by HubSpot Media // Production by Arie Desormeaux // Editing by Ezra Bakker Trupiano /
AI chatbots have linguistic slips when they go off-script
Let’s say you're chatting away with AI — perfect grammar, great vocabulary. Then, boom: a random word in another language! That's the topic for today's “Uncanny AI.” Those moments where it becomes really clear that AI doesn't think like us. Janelle Shane, who writes the AI Weirdness blog, helps explain why AI chatbots do this.
More on this:
“ChatGPT users flummoxed after AI bot starts inserting Arabic into responses” from The New York Post
“ChatGPT is mixing languages or Answers are Wrong!” from OpenAI Developer Community
The Engine Powering Open-Source AI
Elena Burger and Matt Bornstein are joined by Simon Mo, co-founder and CEO of Inferact, the open-source inference engine powering many of today's most advanced AI applications. Together, they explore how open-source AI evolved from a research project into critical infrastructure, why inference has become one of the most important layers of the AI stack, and what it takes to bring frontier intelligence to developers around the world.
The conversation covers vLLM's origins, the rise of open-weight models, why companies increasingly want control over their AI infrastructure, and how open-source inference enables the next generation of AI applications. They also discuss model licensing, the economics of open-weight AI, Kimi K3, distillation, AI infrastructure, and why Simon believes the gap between open and closed models is rapidly disappearing.
Resources:
Follow Simon Mo on X: https://x.com/simon_mo_
Follow Matt Bornstein on X: https://x.com/BornsteinMatt
Follow Elena Burger on X: https://x.com/VirtualElena
Follow Inferact: https://x.com/inferact
Stay Updated:
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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.
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The Cyclospora Mystery: How Human Poop Got on So Much Lettuce
U.S. health officials linked six more states to what’s now the largest outbreak of cyclospora in American history — an outbreak that has contributed to at least two deaths, sickened thousands of people and left the rest of us increasingly scared of salad.
Today, Christina Jewett and Caroline Hopkins Legaspi, two public health reporters who have covered the parasite for The New York Times, discuss what’s been learned about where it comes from, how it spread so quickly and why our food safety system seems to be powerless to stop it.
Guest:
Christina Jewett, covers the Food and Drug Administration for The New York Times.
Caroline Hopkins Legaspi, a health reporter focusing on nutrition and sleep for The New York Times.
Background reading:
Taco Bell and the food distributor Sysco have pulled Taylor Farms lettuce from supply chains after it was linked to cyclosporiasis.
The Centers for Disease Control and Prevention has linked six more states to the cyclospora outbreak associated with iceberg lettuce.
Photo: Michelle V. Agins / The New York Times
For more information on today’s episode, visit nytimes.com/thedaily. Transcripts of each episode will be made available by the next workday.
Subscribe today at nytimes.com/podcasts or on Apple Podcasts and Spotify. You can also subscribe via your favorite podcast app here https://www.nytimes.com/activate-access/audio?source=podcatcher. For more podcasts and narrated articles, download The New York Times app at nytimes.com/app.
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The Terminal as an Agentic Interface
The terminal has been a constant in software development for decades. It has remained largely unchanged while everything around it transformed. However, as AI agents have become central to the developer workflow, the terminal is emerging as a natural home for agentic development, and a new category of tooling is forming around it.
Warp is a popular Rust-based terminal and agentic development environment. The company recently open-sourced its codebase and launched Oz, its cloud agent infrastructure product aimed at helping enterprises automate software development at scale.
Zach Lloyd is the co-founder and CEO of Warp, and a former principal engineer at Google where he led engineering on the Google Docs suite. In this episode, Zach joins Gregor Vand to discuss how Warp has evolved over the years, why the terminal is better suited than the IDE for agentic development, how Oz approaches the governance and auditability challenges enterprises face with AI agents, and more.
Sponsorship inquiries:
sponsor@softwareengineeringdaily.com
The post The Terminal as an Agentic Interface appeared first on Software Engineering Daily.
Models, Harnesses, and Multi-Agent Systems
AI has moved far beyond chatbots, but what exactly are AI models, agents, agent harnesses, and multi-agent systems, and why do they matter?
In this episode, Daniel and Chris break down the terminology behind today's AI landscape, explain the differences between AI features and autonomous agents, and explore why organizations are shifting toward fleets of AI agents powered by multiple models. They also discuss open vs. closed models, enterprise AI architectures, vendor lock-in, and practical ways to begin adopting agentic AI in your own organization.
If you feel left behind by this ongoing agentic AI revolution that has rapidly accelerated to warp speed, then this episode is the catch-up primer you've been waiting for!
Featuring:
Chris Benson – Website, LinkedIn, Bluesky, GitHub, X
Daniel Whitenack – Website, GitHub, X
Sponsors:
Framer: The enterprise-grade website builder that lets your team ship faster. Get 30% off at framer.com/practicalai
Midwest AI Summit: Join AI practitioners on October 15 in Indianapolis for practical sessions, hands-on discussions, and real-world AI solutions. Use code PracticalAI20 to save 20% on your registration. https://midwestaisummit.com/#tickets
Prediction Guard: A self-hosted AI control plane for running agents in high impact environments. predictionguard.com/practicalai
Resources and Events:
Prior Webinars from our partner Prediction Guard
Midwest AI Summit 2026
Can Data Centers Be Done Right?
As the AI boom fuels a massive data-center buildout, communities across the country are pushing back. Kara speaks with environmental activist and consumer advocate Erin Brockovich, Utah climate scientist Logan Mitchell, Virginia organizer Elena Schlossberg and Lansing, Mich., Mayor Andy Schor about the industry’s environmental and political impact.
They examine the secretive deals and tax incentives behind many data-center projects, and they debate whether even responsibly designed developments can win community support.
The panel also explores what meaningful guardrails might look like, whether cleaner energy and greater transparency could make data centers a genuine public benefit, and if it’s even possible to shift public opinion as data centers become increasingly wrapped up in a broader backlash against AI.
Questions? Comments? Email us at on@voxmedia.com or find us on YouTube, Instagram, TikTok, Threads, and Bluesky @onwithkaraswisher.
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Always be the challenger, with Savannah Bananas founder Jesse Cole
Jesse Cole loved baseball. He also knew most people thought it was too long and boring. So he disrupted America’s pastime by putting on a yellow tux - and an incredible show. The founder of the Savannah Bananas welcomed host Jeff Berman to Anaheim Stadium before a show recently to talk about how he’s scaling Fans First Entertainment into a growing league that sells out pro sports stadiums all over the country.
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The left and right agree on one thing: no data centers
Our guest today is Gaby Del Valle, a policy reporter here at The Verge, and we’re discussing the growing backlash against AI data centers. Gaby recently reported a fantastic piece about Hernando County, Florida, where last month the county commission unanimously approved a year-long moratorium on data center construction.
So I wanted Gaby to talk me through what these protests look like on the ground, from voters whose party affiliations have typically aligned them with big business.
Read the full interview transcript on The Verge.
Links:
Right-wingers protesting data centers have a lot in common with the left | The Verge
No data centers in my backyard | Jasmine Sun
Who’s afraid of the big, bad GPU? | The Verge
NY becomes the first state to enact a data center moratorium | The Verge
The fight against AI data centers is just beginning | The Verge
Florida gives millions in tax breaks to data centers under DeSantis-backed law | Tampa Bay Times
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Credits:
Decoder is a production of The Verge and part of the Vox Media Podcast Network.
Decoder is produced by Kate Cox and Nick Statt and edited by Ursa Wright. Our supervising producer is Greg Ott, and our editorial director is Kevin McShane.
The Decoder music is by Breakmaster Cylinder.
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(Preview) Microsoft’s Plan for Platform Survival, Meta and the Market’s Permission, A Lack of Situational Awareness
On today’s show Ben and Andrew begin with Microsoft, Meta and Google in the wake of their latest earnings reports. First: Microsoft’s push to be the middle layer for enterprise AI, threats to the company’s competitive position in the long run, and the subtext of the open weights open letter frenzy two weeks ago. Then: Parsing Google and Meta strategies as Google hedges its frontier bets, while Meta continues its frontier spending and announces questionable plans for an enterprise business. At the end: The future of the lending environment for Meta and the other hyperscalers, a bubble check-in, a rundown of what happened between Citadel and the Situational Awareness, close encounters with Ben’s vibe coded app, and an emailer offers a compelling theory on the push for Permanent Daylight Savings Time.
To email the show: email@sharptech.fm
@SharpTechPodcast Channel — YouTube
@Stratechery Channel — YouTube
Microsoft Earnings, Microsoft vs. Meta, The Efficiency Payoff — Stratechery Update
Meta Earnings, Meta’s Timing Problems, The Financial Tail — Stratechery Update
Google Earnings, The Frontier Case, Amazon Earnings — Stratechery Update
Microsoft’s Monopoly Hangover — Stratechery
Citadel Securities Sees Warsh Delivering Surprise Fed Hike — Bloomberg
Citadel Buys Situational Awareness’s Stock Portfolio After Big Losses in AI — Wall Street Journal
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Sam Harris on The Democrats’ Far-Left Problem
Scott Galloway speaks with neuroscientist and philosopher Sam Harris about why social media rewards political extremism, how our devices have made sustained attention nearly impossible, and why reclaiming control of our minds may be the key to a happier life.
They also discuss the erosion of trust in expertise, the dangers of the AI arms race, and why Democrats need to draw a clearer line against the far left.
Subscribe to Prof G+ to join our next livestream at profgmedia.com. And if you're not already reading Sam’s work, check out his Substack.
PLUS! Join us for a live Prof G Pod recording at the Odoo Experience conference in San Francisco on Sept 3. You can register for the conference here.
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Brad Setser on the US's Unusual Japanese Yen Intervention
Last week, the US joined forces with Japan to try to stop the yen’s slide. It’s the first time the two sides have intervened in the Japanese currency in 15 years, and in many ways it was an unprecedented and unusual move, with Treasury Secretary Scott Bessent choosing to sell euros (as opposed to dollars) and the use of a little-known Federal Reserve repo facility. So why did the yen’s value drop so precipitously in the first place? And will this intervention be enough to stop it? Brad Setser, senior fellow at the Council on Foreign Relations, explains why the Bank of Japan initially refrained from raising rates, why East Asian currencies (not just the yen) have been so weak lately, the improving fiscal outlook for Japan, and what to look out for next.
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Essentials: Control Your Brain Chemistry for Focus, Motivation & Well-Being
In this Huberman Lab Essentials episode, I explain how key neuromodulators shape motivation, energy, focus and mood throughout the day. I also describe a toolkit of science-supported behavioral, nutritional and supplement-based strategies to increase baseline levels for each neuromodulator, which can be modified to support your specific health and performance goals.
Read the episode show notes at hubermanlab.com.
Thank you to our sponsors
AG1: https://drinkag1.com/huberman
Eight Sleep: https://eightsleep.com/huberman
ROKA: https://roka.com/huberman
Timestamps
(00:00:00) Optimize Neurochemicals for Health
(00:00:27) Neuromodulator Levels & 3 Daily Phases
(00:05:07) Hormones Modulate Neuromodulators
(00:06:56) Sponsor: Eight Sleep
(00:08:13) Effects of Key Neuromodulators
(00:10:16) Increase Motivation & Dopamine, Tools: Morning Sunlight; Caffeine
(00:13:30) Dopamine Supplements: Mucuna Pruriens, L-Tyrosine, Phenethylamine (PEA)
(00:16:34) Increase Dopamine, Tool: Deliberate Cold Exposure
(00:19:18) Sponsor: AG1
(00:20:31) Increase Epinephrine (Adrenaline) & Energy, Tools: Exercise, Cyclic Hyperventilation
(00:24:56) Enhance Focus & Acetylcholine: Choline-Rich Foods, Nicotine
(00:27:11) Acetylcholine Supplements: Alpha-GPC, Huperzine
(00:28:05) Sponsor: ROKA
(00:29:21) Serotonin & Mood, Tools: Gratitude, Tryptophan-Rich Foods
(00:31:49) Serotonin Supplement: Myo-inositol
(00:32:26) Using the Neurochemical Toolkit for Your Goals
Disclaimer & Disclosures
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Advice Line: "Strategy Sessions"
Today’s callers: Tony in Michigan is considering bringing on partners to run different parts of his brew pub and theater business. Then Monica in London is exploring the best way to reach style-conscious parents with her line of children’s clothes. And Sandy in Colorado is seeking the ideal pricing strategy to bring his adaptive test prep platform to schools nationwide.
Thank you to the founders of Hearsay Brewing and Theater, Tres London and Brain Buffs for being a part of our show.
If you’d like to be featured on a future Advice Line episode—where Guy and former show guests take questions from early-stage founders—leave us a one-minute message that tells us about your business and a specific question you’d like answered. Send a voice memo to hibt@id.wondery.com or call 1-800-433-1298.
And be sure to listen to our Advice Line episodes with Jeffrey Hollender of Seventh Generation, Sarah LaFleur of M.M LaFleur and Shazi Visram of Happy Family Organics.
This episode was produced by Kerry Thompson with music by Ramtin Arablouei. It was edited by John Isabella. Our audio engineer was Jimmy Keeley.
You can follow HIBT on X & Instagram and sign up for Guy’s free newsletter at guyraz.com or on Substack.
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
20VC: Airtable Sold for $1.285BN | Leo Achenbrenner's Situational Awareness Blows Up | Moonshot AI Raises $3.5B at $35B | Anthropic Model Breaches Three Companies' Security | Big Tech Earnings: Why Palantir Beat The Rest
Special Guest: Nikesh Arora, CEO @ Palo Alto Networks.
AGENDA:
04:50 Airtable Sold to Bending Spoons for $1.285B 17:00 Leo Aschenbrenner's Situational Awareness Blows Up as Citadel Buys His $16BN Book 22:30 Anthropic's AI Models Breach Three Companies as Cyber Threat Accelerates 33:35 Moonshot AI Raises $3.5B at $35B as Chinese Models Crush AI Prices 38:05 Valar Atomics Triples to $6B as Sequoia Bets on Nuclear Power for AI 42:50 OpenAI and Anthropic Could Trigger a Massive Public-Market Dislocation 52:55 Big Tech and Palantir Earnings Ignite the Next Phase of the AI Gold Rush 1:04:30 Procore Buys DroneDeploy for $900M in a High-Stakes 12x Revenue Bet 1:10:55 Scale AI Hits $1.5B ARR After the Meta Deal Left It for Dead
LOW - Trailer
After 8 years, LOW is finally here. A story about the weight of being and the wreckage of waking up. Five episodes. Five descents. LOW is an audio journey into the unlit corners of human experience. Choices we made in the dark, the silences we carry, and what remains when we stop running from ourselves.
LOW a new Limited Series from the Jack Rhysider will be releasing to the public for free soon, but you can hear it now as a Darknet Diaries Plus subscriber. Go to plus.darknetdiaries.com and subscribe for access to all five episodes of LOW along with twelve bonus episodes of Darknet Diaries and every episode ad-free.
Man Who Owns 4% Of All Bitcoin: Sell Your Kidney But Keep The Bitcoin, UNLESS… | Michael Saylor
The Diary Of A CEO:
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Sponsors:
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The Biggest Myths About Dating (debunked) - Psychology Roundtable - #1133
In this evolutionary psychology roundtable, we explore:
- If 20% of the men actually get 80% of the attention.
- The biggest red and green flags to look out for in the dating pool.
- Why women's sexual desire fades faster than men's.
- and much more…
Guests:
- Macken Murphy is an evolutionary biologist at the University of Melbourne, a writer and a podcaster.
- Steve Stewart-Williams is an evolutionary psychologist, a professor, and an author.
- Rob Henderson holds a PhD in psychology from the University of Cambridge and is a Senior Fellow at the Manhattan Institute.
Sponsors:
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Get a free bottle of D3K2, an AG1 Welcome Kit, and more when you first subscribe at https://ag1.info/modernwisdom
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Get a Free Sample Pack of LMNT’s most popular flavours with your first purchase at https://drinklmnt.com/modernwisdom
Get ChatGPT to explore ideas, solve problems, and learn faster at https://chatgpt.com
Timestamps:
(0:00) Is This the Most Attractive Dance Move?
(3:14) Does Looksmaxxing Give Women the Ick?
(13:07) Why Do We Get the Ick?
(16:52) Are Chads Stealing All the Women?
(25:23) Is Marriage Affirmative Action for Men?
(31:00) Are Humans Meant to Be Serial Monogamists?
(34:52) How Rich Women Change Men’s Resourcefulness
(44:18) Abundance vs Scarcity: What’s More Attractive?
(55:34) Do High-Earning Women Have Higher Standards?
(01:05:03) Can Surveys Accurately Measure Sex Differences?
(01:10:36) Are Dating App Users Worse Partners?
(01:16:53) What Matters More: Height or Looks?
(01:20:46) Why Male Beautification Is Exploding
(01:31:27) Do Women Prefer Formidable Men?
(01:35:22) The Rise of Female Teacher Sex Scandals
(01:42:56) Is Being Desired What Women Want Most?
(01:47:32) The Dangers of Minimising Sex Differences
(01:50:46) The Latest Evidence on Mate Switching
(01:52:20) Why Marriage Kills Women’s Sex Drive
(01:56:40) How Do We Determine Human Nature?
(02:03:34) What Do Lesbians Find Attractive?
(02:05:57) Where to Find the Guys
Extra Stuff:
Get my free reading list of 100 books to read before you die: https://chriswillx.com/books
Try my productivity energy drink Neutonic: https://neutonic.com/modernwisdom
Episodes You Might Enjoy:
#577 - David Goggins - This Is How To Master Your Life: lnkfi.re/SN-Goggins
#712 - Dr Jordan Peterson - How To Destroy Your Negative Beliefs: lnkfi.re/SN-Peterson
#700 - Dr Andrew Huberman - The Secret Tools To Hack Your Brain: lnkfi.re/SN-Huberman
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