In this episode, Logan is joined by Zach Weinberg (Co-Founder/CEO @ Curie.Bio) and Derek Thompson (writer at The Atlantic) for a candid discussion on the state of U.S. healthcare and scientific progress. They unpack what went right, and wrong, with COVID vaccine policy, the public backlash against mRNA technology, and the ripple effects on trust in science.
The conversation also dives into the real reasons behind NIH budget cuts, the economics of drug discovery, and the business incentives in medical R&D. It’s a sharp, thought-provoking look at the intersection of policy, innovation, and public perception.
(00:00) Introduction to Drug Pricing in the US
(00:23) Broad Healthcare Topics and Open-Ended Discussion
(02:37) COVID-19 Vaccines: Successes and Public Perception
(06:21) The Evolution of COVID-19 and Vaccine Efficacy
(07:59) Public Policy and Vaccine Mandates
(13:10) Impact of School Closures and Public Sentiment
(19:23) NIH Funding and the Importance of Basic Research
(25:04) Challenges in Science Funding and Public Perception
(35:19) Government vs. Private Investment in Science
(36:40) Operation Warp Speed: A Case Study
(39:07) Antibiotic Resistance Crisis
(43:22) The Drug Pricing Debate
(44:05) Challenges in Drug Discovery
(54:06) Regulatory Hurdles in Medical R&D
(58:06) The Future of Drug Development
(01:04:19) Concluding Thoughts
Executive Producer: Rashad Assir
Producer: Leah Clapper
Mixing and editing: Justin Hrabovsky
Check out Unsupervised Learning, Redpoint's AI Podcast: https://www.youtube.com/@UCUl-s_Vp-Kkk_XVyDylNwLA
🎙 Listen to the show
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About the Show
Logan Bartlett is a Software Investor at Redpoint Ventures - a Silicon Valley-based VC with $6B AUM and investments in Snowflake, DraftKings, Twilio, and Netflix. In each episode, Logan goes behind the scenes with world-class entrepreneurs and investors. If you're interested in the real inside baseball of tech, entrepreneurship, and start-up investing, tune in every Friday for new episodes.
In this episode, Derek Thompson (Writer, The Atlantic) delves into the tumultuous nature of Trump’s trade policies, especially regarding tariffs, and how they impact American manufacturing and global markets. They discuss the constant changes in policy, the resulting uncertainty for industries like automotive and aerospace, and the mismatch between Trump’s ‘madman strategy’ and effective industrial policy. The conversation also explores the broader economic consequences, including stock market volatility, housing affordability issues, and the role of government in promoting economic growth and innovation.
(00:00) Intro
(00:20) Trump's Trade Policy and Its Implications
(01:30) The Uncertainty of Tariff Policies
(02:12) Impact on American Manufacturing
(05:15) Stock Market Reactions
(07:00) Debating the Effectiveness of Tariffs
(10:02) Wall Street vs. Main Street
(18:44) Housing and Healthcare Challenges
(34:53) Historical Context of Housing Regulations
(41:48) The Reality of Construction Jobs
(42:35) The American Dream and Housing Costs
(42:57) The 30-Year Mortgage and Its Impact
(43:48) Comparing Home Ownership to Stock Market Investments
(45:14) Political Reception of the Book 'Abundance'
(46:17) Pro-Business Democrats and Government's Role
(48:38) The Need for Aggressive Democratic Leaders
(51:18) The Importance of Economic Growth
(01:01:26) Debating Government's Role in Industrial Policy
(01:03:34) Challenges in the Semiconductor Industry
(01:13:19) The Housing Problem in New York City
(01:15:26) Conclusion and Final Thoughts
Executive Producer: Rashad Assir
Producer: Leah Clapper
Mixing and editing: Justin Hrabovsky
Check out Unsupervised Learning, Redpoint's AI Podcast: https://www.youtube.com/@UCUl-s_Vp-Kkk_XVyDylNwLA
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About the Show
Logan Bartlett is a Software Investor at Redpoint Ventures - a Silicon Valley-based VC with $6B AUM and investments in Snowflake, DraftKings, Twilio, and Netflix. In each episode, Logan goes behind the scenes with world-class entrepreneurs and investors. If you're interested in the real inside baseball of tech, entrepreneurship, and start-up investing, tune in every Friday for new episodes.
Debate between Keith Rabois and Zach Weinberg on what tariffs are actually trying to accomplish. One core theme: Tariffs aren’t fully about “bringing back factories,” but rather a negotiation tool to eliminate foreign trade barriers - ultimately aiming to increase free trade, not restrict it.
We also got into:
- What each of them would do if they were in charge
- Whether the trade deficit is a meaningful metric or just a misunderstood talking point
- If tariffs could be part of an initiative to replace income tax — shifting toward a more consumption-based tax system
- If tariffs could successfully be used as a non-military tool to reduce drug supply to the US
- If there’s a major disconnect between the new administration’s rhetoric and the actual economic goals behind the policy
One of the deepest economic conversations from the show’s recent history — and a rare debate where both sides had real logic behind their views.
(00:00) Introduction and Host's Biases
(00:46) Keith's Perspective on Tariffs
(03:05) Zach's Perspective and Clarifying Questions
(05:14) Debating Tariff Strategies
(07:45) Economic Implications and Free Trade
(13:31) Trump's Tariff Policies and Goals
(16:57) Global Trade and Protectionism
(25:52) Final Thoughts on Tariffs and Trade
(29:16) Discussion on Trade Tariffs and Partners
(30:17) Impact of Tariffs on GDP and Debt
(31:20) Political Coalitions and Trade Policies
(32:00) Tariffs as Consumer Taxes
(33:30) Debate on Trade Deficit and Tariff Rates
(36:53) Regulatory Reforms and Economic Policies
(47:25) Fentanyl Crisis and Trade Negotiations
(51:06) Closing Remarks and Future Topics
Executive Producer: Rashad Assir
Producer: Leah Clapper
Mixing and editing: Justin Hrabovsky
Check out Unsupervised Learning, Redpoint's AI Podcast: https://www.youtube.com/@UCUl-s_Vp-Kkk_XVyDylNwLA
🎙 Listen to the show
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About the Show
Logan Bartlett is a Software Investor at Redpoint Ventures - a Silicon Valley-based VC with $6B AUM and investments in Snowflake, DraftKings, Twilio, and Netflix. In each episode, Logan goes behind the scenes with world-class entrepreneurs and investors. If you're interested in the real inside baseball of tech, entrepreneurship, and start-up investing, tune in every Friday for new episodes.
In this freeform episode, Logan sits down with Zach Weinberg (Co-Founder and CEO of Curie.Bio) to break down two of the biggest storylines in tech: tariffs and AI.
They banter through the core arguments for and against tariffs, including national security, domestic employment, and negotiation power. Plus, they revisit what’s happened in past trade wars and share predictions on the real economic consequences this time around.
Logan and Zach also discuss OpenAI’s $40B raise and the broader race for AI dominance—can OpenAI maintain its lead against tech giants like Google and Apple? They debate the limits of product defensibility, the power of platform defaults, and the strategic moves OpenAI might need to make to stay ahead.
Topics include:
The arguments for and against tariffs
What happened during past U.S. tariff cycles—and how this one compares
Whether OpenAI can maintain its edge in a world of native AI platforms
A possible playbook for OpenAI to build user lock-in beyond utility
What this era of AI competition means for the U.S.—and what could derail it
https://fdra.org/wp-content/uploads/2025/03/Trade-War-Lessons-from-the-Past-2025.pdf?utm_source=newsletter&utm_medium=email&utm_campaign=newsletter_axiosmacro&stream=business
(00:00) Intro
(01:35) Liberation Day and Global Trade
(02:13) Freeform Discussion on Various Topics
(02:44) Podcasting and VC Life
(03:32) Debating Tariffs and National Security
(11:26) Arguments Against Tariffs
(22:19) Historical Context of Tariffs
(26:58) Economic Predictions and Stagflation
(33:39) The Forgotten Lessons of Recessions
(36:02) The Fixed vs. Growth Mindset in Economics
(37:17) The Democratic Party's Shift on Economic Policies
(42:33) The Rise of Populism and Its Impact
(50:28) OpenAI's Explosive Growth and Challenges
(54:28) The Competitive Landscape of AI
(58:33) The Future of AI and Consumer Behavior
(01:07:20) The Role of Social Networking in AI's Future
(01:10:43) Wildcard: The Role of XAI and Grok
Executive Producer: Rashad Assir
Producer: Leah Clapper
Mixing and editing: Justin Hrabovsky
Check out Unsupervised Learning, Redpoint's AI Podcast: / @redpointai
🎙 Listen to the show
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🎥 Subscribe on YouTube: / @theloganbartlettshow
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About the Show
Logan Bartlett is a Software Investor at Redpoint Ventures - a Silicon Valley-based VC with $6B AUM and investments in Snowflake, DraftKings, Twilio, and Netflix. In each episode, Logan goes behind the scenes with world-class entrepreneurs and investors. If you're interested in the real inside baseball of tech, entrepreneurship, and start-up investing, tune in every Friday for new episodes.
Zach Weinberg is the Co-Founder and CEO of Curie.Bio, which has raised over $500 million to combine early-stage investing in biotech and drug discovery copiloting. He is also the co-founder of Flatiron Health, which sold to Roche for $1.9B, and Invite Media, which sold to Google when he was 21.
In the episode, Zach dives into the current venture market landscape, private company valuation and funding trends, and the art of reshaping company culture. Zach unveils his unique blueprint for interviewing top-tier candidates and holding them accountable, as well as the case study tactics he uses to make more confident hires.
(00:00) Intro
(00:44) The Art of Hiring: Strategies for Building a Winning Team
(01:22) Market Dynamics: A Deep Dive into Valuations and Trends
(06:29) The AI Revolution: Impact on Valuations and the Future of Tech
(08:26) Cultural Shifts: Navigating the Changing Landscape of Startup Culture
(31:36) The Accountability Framework: A Blueprint for Success
(38:50) The Importance of Third-Party Hiring Reviews
(40:19) Cultivating a Culture of Accountability and Skill Testing
(41:23) Insights on Case-Based Interviewing and Its Impact
(43:07) Navigating the Complexities of Hiring for Unique Roles
(43:50) The Art of Case Design in Interviews
(49:52) Leveraging Take-Home Assignments for Deeper Insights
(58:40) The Challenges of Remote Work and Building Credibility
(01:00:39) Adapting Hiring Practices for Remote and Hybrid Models
(01:03:27) The Value of References and Real-World Testing in Hiring
(01:12:59) The Foundational Role of People in Business Success
(01:16:11) Reflecting on the Journey and Looking Ahead
Produced: Rashad Assir & Leah Clapper
Mixed and edited: Justin Hrabovsky
Executive Producer: Josh Machiz
Check out Unsupervised Learning, Redpoint's AI Podcast: https://www.youtube.com/ @RedpointAI
🎙 Listen to the show
Apple Podcasts: https://podcasts.apple.com/us/podcast/the-logan-bartlett-show/id1606770839
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🎬 Clips on TikTok - https://www.tiktok.com/@theloganbartlettshow
About the Show
Logan Bartlett is a Software Investor at Redpoint Ventures - a Silicon Valley-based VC with $6B AUM and investments in Snowflake, DraftKings, Twilio, and Netflix. In each episode, Logan goes behind the scenes with world-class entrepreneurs and investors. If you're interested in the real inside baseball of tech, entrepreneurship, and start-up investing, tune in every Friday for new episodes.
Executive Producer: Rashad Assir
Producer: Leah Clapper
Mixing and editing: Justin Hrabovsky
Check out Unsupervised Learning, Redpoint's AI Podcast: https://www.youtube.com/@UCUl-s_Vp-Kkk_XVyDylNwLA
🎥 Subscribe on YouTube: https://www.youtube.com/channel/UCugS0jD5IAdoqzjaNYzns7w?sub_confirmation=1
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About the Show
Logan Bartlett is a Software Investor at Redpoint Ventures - a Silicon Valley-based VC with $6B AUM and investments in Snowflake, DraftKings, Twilio, and Netflix. In each episode of The Logan Bartlett Show, we sit down with the people behind today’s most important startups and extract the tactics, lessons, and frameworks they’ve learned the hard way. Conversations span hiring to GTM, product, growth, fundraising and everything in between - collectively forming the ultimate playbook to make you a better CEO, investor or board member.
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Zach Weinberg is the Founder and CEO of Curie.Bio, a $520M fund transforming biotech.
In the episode, Logan and Zach banter on the current state of the venture capital industry, as well as everything from remote work, artificial intelligence, and founder advice.
Prior to Curie.Bio, Zach was the Co-Founder at Flatiron Health (acquired by Roche) and the Co-Founder at Invite Media (acquired by Google).
(0:00) Intro
(1:29) NASDAQ Closing Bell Ceremony
(7:09) Publicly launching Curie.Bio and working from home
(34:11) State of the venture market
(45:26) What kind of investing council are you giving?
(50:07) You don't get fired if everyone else sucked alongside you
(53:24) Venture is such a big industry now, generalizations don't work
(1:00:34) The biggest companies will create value out of AI
(1:08:21) People didn't learn any lessons from crypto
(1:13:42) What has Zach excited outside of biotech
(1:22:26) Only engaging in arguments that matter to you
Mixed and edited: Justin Hrabovsky
Produced: Rashad Assir
Executive Producer: Josh Machiz
Music: Griff Lawson
🎙 Listen to the show
Apple Podcasts: https://podcasts.apple.com/us/podcast/three-cartoon-avatars/id1606770839
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About the Show
Logan Bartlett is a Software Investor at Redpoint Ventures - a Silicon Valley-based VC with $6B AUM and investments in Snowflake, DraftKings, Twilio, and Netflix. In each episode, Logan goes behind the scenes with world-class entrepreneurs and investors. If you're interested in the real inside baseball of tech, entrepreneurship, and start-up investing, tune in every Friday for new episodes.
Executive Producer: Rashad Assir
Producer: Leah Clapper
Mixing and editing: Justin Hrabovsky
Check out Unsupervised Learning, Redpoint's AI Podcast: https://www.youtube.com/@UCUl-s_Vp-Kkk_XVyDylNwLA
🎥 Subscribe on YouTube: https://www.youtube.com/channel/UCugS0jD5IAdoqzjaNYzns7w?sub_confirmation=1
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About the Show
Logan Bartlett is a Software Investor at Redpoint Ventures - a Silicon Valley-based VC with $6B AUM and investments in Snowflake, DraftKings, Twilio, and Netflix. In each episode of The Logan Bartlett Show, we sit down with the people behind today’s most important startups and extract the tactics, lessons, and frameworks they’ve learned the hard way. Conversations span hiring to GTM, product, growth, fundraising and everything in between - collectively forming the ultimate playbook to make you a better CEO, investor or board member.
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In the 54th episode of The Logan Bartlett Show Zach Weinberg returns to share everything from “catching the bug” of the internet in college, to founding and exiting 2 companies, to his latest venture Curie.Bio; a drug discovery co-pilot and seed investment firm focused on Biotech. Lots of interesting comparisons drawn between Biotech today and the early days of tech.
(0:00) Intro
(1:25) Welcome Zach Weinberg
(3:21) Background
(6:46) Starting EatNow
(9:56) Why healthcare?
(19:55) The best way to learn about an industry
(29:08) Building and Selling Flatiron
(36:10) Buying a CHR
(46:06) Curie.Bio
(1:17:19) Going public
Mixed and edited: Justin Hrabovsky
Produced: Andrew Nadeau and Rashad Assir
Executive Producer: Josh Machiz
Music: Griff Lawson
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Apple Podcasts: https://podcasts.apple.com/us/podcast/three-cartoon-avatars/id1606770839
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About the Show
Logan Bartlett is a Software Investor at Redpoint Ventures - a Silicon Valley-based VC with $6B AUM and investments in Snowflake, DraftKings, Twilio, Netflix. In each episode, Logan goes behind the scenes with world-class entrepreneurs and investors. If you're interested in the real inside baseball of tech, entrepreneurship, and start-up investing, tune in every Friday for new episodes.
Executive Producer: Rashad Assir
Producer: Leah Clapper
Mixing and editing: Justin Hrabovsky
Check out Unsupervised Learning, Redpoint's AI Podcast: https://www.youtube.com/@UCUl-s_Vp-Kkk_XVyDylNwLA
🎥 Subscribe on YouTube: https://www.youtube.com/channel/UCugS0jD5IAdoqzjaNYzns7w?sub_confirmation=1
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About the Show
Logan Bartlett is a Software Investor at Redpoint Ventures - a Silicon Valley-based VC with $6B AUM and investments in Snowflake, DraftKings, Twilio, and Netflix. In each episode of The Logan Bartlett Show, we sit down with the people behind today’s most important startups and extract the tactics, lessons, and frameworks they’ve learned the hard way. Conversations span hiring to GTM, product, growth, fundraising and everything in between - collectively forming the ultimate playbook to make you a better CEO, investor or board member.
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In the 42nd episode, Zach Weinberg returns to have everything he’s said about crypto suddenly proven right. Logan and Zach break down FTX, DeFi, SBF and venture’s role in it all. Plus why you can’t spot a successful company in finance like you can in tech, what makes a smart founder, and Rashad joins to help recap the last week of Elon and Twitter.
(0:00) Intro
(2:02) This week on Twitter
(10:01) The FTC
(13:41) What’s next?
(21:37) Other social platforms
(23:57) Welcome back Zach Weinberg
(27:56) Zach’s take on FTX
(43:17) Smart people don’t get rich quick
(44:52) Venture’s culpability
(51:35) Interest rates
(54:48) Would DeFi have been better?
(1:01:23) End of Web3?
(1:07:43) Outro
Show Notes:
https://milkyeggs.com/?p=175
https://forum.effectivealtruism.org/posts/xafpj3on76uRDoBja/the-ftx-future-fund-team-has-resigned-1?commentId=hpP8EjEt9zTmWKFRy
Mixed and edited: Justin Hrabovsky
Produced: Andrew Nadeau and Rashad Assir
Executive Producer: Josh Machiz
Music: Griff Lawson
🎙 Listen to the show
Apple Podcasts: https://podcasts.apple.com/us/podcast/three-cartoon-avatars/id1606770839
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About the Show
A Saturday morning podcast hosted by Logan Bartlett (Partner and Managing Director at Redpoint Ventures) covering the tech news with his friends and other people with industry expertise.
Executive Producer: Rashad Assir
Producer: Leah Clapper
Mixing and editing: Justin Hrabovsky
Check out Unsupervised Learning, Redpoint's AI Podcast: https://www.youtube.com/@UCUl-s_Vp-Kkk_XVyDylNwLA
🎥 Subscribe on YouTube: https://www.youtube.com/channel/UCugS0jD5IAdoqzjaNYzns7w?sub_confirmation=1
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About the Show
Logan Bartlett is a Software Investor at Redpoint Ventures - a Silicon Valley-based VC with $6B AUM and investments in Snowflake, DraftKings, Twilio, and Netflix. In each episode of The Logan Bartlett Show, we sit down with the people behind today’s most important startups and extract the tactics, lessons, and frameworks they’ve learned the hard way. Conversations span hiring to GTM, product, growth, fundraising and everything in between - collectively forming the ultimate playbook to make you a better CEO, investor or board member.
Tap follow and enable notifications to stay ahead of the game.
(01:35) Dan Primack Breaks Down Elon Musk’s Bid for Twitter but Not Why His Tweets Are So Bad
(22:07) Zach Weinberg Debuts as a Cartoon Avatar
(32:06) Crypto’s a Security but Shut Up About It
Follow the show:
https://twitter.com/cartoonavatars
https://www.instagram.com/cartoonavatars/
https://www.tiktok.com/@cartoonavatars
Follow the hosts:
https://twitter.com/zck
https://twitter.com/zachweinberg
https://twitter.com/loganbartlett
Mixed and edited: Justin Hrabovsky
Produced: Andrew Nadeau and Rashad Assir
Executive Producer: Josh Machiz
Music: Griff Lawson
Show Notes:
Elon Poll: https://twitter.com/elonmusk/status/1514698036760530945?
Cuban Tweet: https://twitter.com/mcuban/status/1514609934897336324?s=20&t=-p0_8TocoAHVt2mBCsVHJg
Difference between BTC and ETH: https://twitter.com/Carnage4Life/status/1512728493670371329?s=20&t=-Hg2wh89zeiR41gd9i3UAg
Newcomer on the leaked decks: https://www.newcomer.co/p/inside-3-crypto-funds-investor-decks
Executive Producer: Rashad Assir
Producer: Leah Clapper
Mixing and editing: Justin Hrabovsky
Check out Unsupervised Learning, Redpoint's AI Podcast: https://www.youtube.com/@UCUl-s_Vp-Kkk_XVyDylNwLA
🎥 Subscribe on YouTube: https://www.youtube.com/channel/UCugS0jD5IAdoqzjaNYzns7w?sub_confirmation=1
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🎬 Clips on TikTok - https://www.tiktok.com/@theloganbartlettshow
About the Show
Logan Bartlett is a Software Investor at Redpoint Ventures - a Silicon Valley-based VC with $6B AUM and investments in Snowflake, DraftKings, Twilio, and Netflix. In each episode of The Logan Bartlett Show, we sit down with the people behind today’s most important startups and extract the tactics, lessons, and frameworks they’ve learned the hard way. Conversations span hiring to GTM, product, growth, fundraising and everything in between - collectively forming the ultimate playbook to make you a better CEO, investor or board member.
Tap follow and enable notifications to stay ahead of the game.
Zach Weinberg is a Co-Founder of Operator Partners, operators funding operators, with no outside LPs, just their own capital. Fun fact, 20VC Fund has actually invested with them in 3 companies from Alt, Dooly.ai and Boom Pay. Prior to founding Operator Partners, Zach was the Co-founder/COO of Flatiron Health (acq @Roche for $2b) and before Flatiron Zach co-founded Invite Media (acq @Google for $81m). If that was not enough, Zach has also been an incredibly successful angel in the past with a portfolio including RigUp, Ro, Color, BlueApron and Plaid to name a few.
In Today's Episode You Will Learn:
1.) How Zach made his way into the world of startups, came to found Flatiron (acq for $2Bn) and how that led to Operator Partners?
2.) How does Zach analyse his own personal capital allocation? How much in funds? How much in cash, equities, direct, credit etc etc? How does Zach analyse his relationship to money? How has it changed over time? How does Zach evaluate his relationship to risk?
3.) What does Zach make of the rise of pre-empted rounds? When should founders takem them vs reject them? How does Zach feel about multi-stage funds re-entering seed aggressively? How does he advise founders? What are the pros and cons of having multi-stage money?
4.) How does Zach think about the importance of ownership? How does Zach analyse the re-investment decision? How does he approach reserve allocation? How does Zach reflect on his own price sensitivity? How has his relationship to price and ownership changed with time?
5.) How does Zach feel about Brian Armstrong's piece on employees bringing their own political and external beliefs into the workplace? Why does Zach believe that companies are not a democracy? Why does Zach believe that we do not live in a democracy any longer?
Item's Mentioned In Today's Episode
Zach's Favourite Book: Calling Bullshit: The Art of Skepticism in a Data-Driven World
Zach's Most Recent Investment: David Energy
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with @vintweeta @pbcancerdoc @sumitshahmd @omnivorousread
Coronavirus is now disrupting the entire health care system, not just because of the burden of dealing with the actual disease itself, but because of everything else that's had to grind to a halt. One of the areas where we really worry about things coming to a total stop like that is, of course, cancer treatment, which can often feel like a race against the clock even under the best conditions.
In this episode, Dr. Bobby Green, MD (Community Oncologist and Chief Medical Officer, Flatiron Health) and Dr. Sumit Shah (Oncologist and Head of Digital Health, Stanford Cancer Center) join a16z's Vineeta Agarwala (physician and general partner) and Hanne Tidnam to talk about what is happening to oncology during the outbreak—how treatment is affected; what kind of clinical decisions oncologists and patients are having to make, and how they're making them; the tech tools that specialists are using, and how they could improve; and what happens to oncology as a whole when it's forced to go virtual.
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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.
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The federal agency known as the FDA, or the Food and Drug Administration, was born over 100 years ago—at the turn of the industrial revolution, in a time of enormous upheaval and change, and rapidly emerging technology. The same could be said to be just as true today. From CRISPR to synthetic biology to using artificial intelligence in medicine, our healthcare system is undergoing massive amounts of innovation and change.
Covering everything from gene-editing your dog to tracking the next foodborne outbreak, this wide-ranging conversation between Principal Commissioner of the FDA Amy Abernethy and Vijay Pande, GP on the Bio Fund at a16z, discusses how the agency is evolving to keep pace with the scientific breakthroughs coming, while staying true to its core mission of assessing safety and effectiveness for consumers in the world of food and medicine.
Highlights:
What the FDA looks like today and the key steps of the FDA process to getting a drug/product to market [2:20]
How to manage a culture when mitigating risk is a top priority while aiming to innovate for the future [5:22]
Creative problem-solving in times of crisis, such as the Opioid crisis [9:58]
Preparing for and preventing drug shortages at scale [13:30]
How advances in bioengineering are transforming healthcare [16:00]
How the FDA is thinking about n=1 therapies and its applications in the future [18:54]
The future of healthcare privacy [26:10]
The ways the clinical trial process are shifting [29:26]
Innovations in Bioengineering as they relate to regulating food in the future [36:02]
How the FDA handles foodborne illnesses and its plans to innovate food safety [39:12]
Discussion about the next 100 years of the FDA [41:25]
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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.
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Veterinary oncology can inform human oncology, and vice versa -- providing a better model for looking at drug performance, interrelationships, and more. Especially when you add in data (there's no "doggy HIPAA!") and networks to get a "living laboratory at scale".
Or so argues Amy Abernethy (Chief Medical and Chief Scientific Officer at Flatiron Health and advisor to One Health), who was recently named the new Principal Deputy Commissioner of the FDA, pending ethics clearance; and Christina Lopes, CEO and co-founder of One Health; in conversation with a16z bio general partner Jorge Conde. Dogs -- as a species, as pets, as companions, as family members -- evolved alongside humans, so are actually more similar to us... not just genetically and in terms of the biologic pathways that may cause cancer, but also in exposure to similar environmental factors as well.
But what does this all mean when it comes to thinking about real-world evidence in science, human clinical trials, and more broadly, building a bio company? How can product designers -- of all kinds -- backwards-architect their product roadmap for data network effects? And how can bio founders keep both a big-picture roadmap in mind while also focusing on specific milestones, and while working across unconnected disciplines as well? We cover all this and more in this special episode of the a16z Podcast, recorded during the recent J.P.M. healthcare conference in San Francisco.
The views expressed here are those of the individual AH Capital Management, L.L.C. (“a16z”) personnel quoted and are not the views of a16z or its affiliates. Certain information contained in here has been obtained from third-party sources, including from portfolio companies of funds managed by a16z. While taken from sources believed to be reliable, a16z has not independently verified such information and makes no representations about the enduring accuracy of the information or its appropriateness for a given situation.
This content is provided for informational purposes only, and should not be relied upon as legal, business, investment, or tax advice. You should consult your own advisers as to those matters. References to any securities or digital assets are for illustrative purposes only, and do not constitute an investment recommendation or offer to provide investment advisory services. Furthermore, this content is not directed at nor intended for use by any investors or prospective investors, and may not under any circumstances be relied upon when making a decision to invest in any fund managed by a16z. (An offering to invest in an a16z fund will be made only by the private placement memorandum, subscription agreement, and other relevant documentation of any such fund and should be read in their entirety.) Any investments or portfolio companies mentioned, referred to, or described are not representative of all investments in vehicles managed by a16z, and there can be no assurance that the investments will be profitable or that other investments made in the future will have similar characteristics or results. A list of investments made by funds managed by Andreessen Horowitz (excluding investments and certain publicly traded cryptocurrencies/ digital assets for which the issuer has not provided permission for a16z to disclose publicly) is available at https://a16z.com/investments/.
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Please note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.
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